"Many Twitter users adopt a "quality not quantity" strategy by only following a certain number of Twitterers. But, by using certain tools and adopting a certain mindset, I think you can achieve both quality and quantity.
"Here's how I follow 2,500 people on Twitter:
"It's a stream, not a publication."
"The more people you follow (your Twitter "friends"), the more chance you have of stumbling across something interesting. The more diverse your Twitter friends are, the more likely you'll stumble across something useful from outside your immediate circles. For me, those are the most interesting Twitter experiences.
"So stop worrying about what you're missing. Focus on what you do see."
Paul Bradshaw - How Do You 'Follow' 2,500 People on Twitter?
[via a Poynter tweet]